Roadmap for the development of candidate vaccines for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

Establishing how the virus enters host cells would indicate a possible route that could be blocked by targeted specific immune responses.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

Identify virus components that interact with cell surface receptors.

What approaches could/should be taken to address the research question?

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures

There has been recognition of the importance of autophagosomes for FMDV entry into the cytoplasm following cell surface receptor binding, and that distinct internal cellular membranes are exploited for viral replication and immune evasion.