Roadmap for the research to underpin the development of control strategies for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

To determine the host-range and role of the different species on long-term maintenance of FMDV.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Define host range determinants at molecular level (e.g. buffalo vs. cattle, SAT1 vs. SAT2 vs. other).
• Investigate key events that define permissiveness.
• Define role of different species on long-term maintenance of FMDV.
• Define role of different species on virus evolution.
• Perform multi-disciplinary data analysis.

What approaches could/should be taken to address the research question?

Further elucidate 3A mutation as best-defined host range determinant.

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures

FMDV has been found in more than 70 species, including cattle, buffalo, sheep, goats, pigs, and deer.