Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmap8
Characterization
Characterization
Research Question
- Characterization of influenza virus (biological, sequences, viruses, phenotype)
Research Gaps and Challenges
- Characterize determinants of high- vs. low-pathogenicity avian influenza also outside the HA cleavage site Inability/ lack of ease in detecting true reassortment vs. Contamination of sample
- Characterize zoonotic propensity
- Limitations for in vivo testing due to animal welfare laws
- Characterize antigenic properties with respect to vaccine susceptibility
- Failure to maintain sample authenticity thus inability to study observed outcomes of infection
- Transparency about human impacts
- Lack of understanding how genomic reassortment is made exactly
Solution Routes
- Loss of function experiments both in vitro and in vivo
- Study virus transmission across interfaces
- Identification of antibody epitopes important for antigenic drift in swine and poultry species
- Development of models to predict epitopes based on HA sequence evolution
- Promotion and adoption of a standard classification scheme (e.g., the global swine clade classification scheme and the H5 clade classification scheme) – and have this classification updated in real time (I.e.: standardized next strain, etc.)
Dependencies
- Virus isolates
- Pathogenicity models
- Interface transmission models
- Genomic surveillance in multiple hosts and even different sites within host
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands