Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmap8
Characterization
Characterization
Research Question
- Characterization of influenza virus (biological, sequences, viruses, phenotype)
Research Gaps and Challenges
- Characterize determinants of high- vs. low-pathogenicity avian influenza also outside the HA cleavage site Inability/ lack of ease in detecting true reassortment vs. Contamination of sample
- Characterize zoonotic propensity
- Limitations for in vivo testing due to animal welfare laws
- Characterize antigenic properties with respect to vaccine susceptibility
- Failure to maintain sample authenticity thus inability to study observed outcomes of infection
- Transparency about human impacts
- Lack of understanding how genomic reassortment is made exactly
Solution Routes
- Loss of function experiments both in vitro and in vivo
- Study virus transmission across interfaces
- Identification of antibody epitopes important for antigenic drift in swine and poultry species
- Development of models to predict epitopes based on HA sequence evolution
- Promotion and adoption of a standard classification scheme (e.g., the global swine clade classification scheme and the H5 clade classification scheme) – and have this classification updated in real time (I.e.: standardized next strain, etc.)
Dependencies
- Virus isolates
- Pathogenicity models
- Interface transmission models
- Genomic surveillance in multiple hosts and even different sites within host
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Intervention Strategies to Control Endemic and New and Emerging Influenza A Virus Infections in Swine
Planned Completion date 04/10/2026
Source Countries:
United States