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Influenza roadmap:
Diagnostic Tests

Roadmap for the development of diagnostic test for influenza

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Characterization

Characterization

Research Question

  • Characterization of influenza virus (biological, sequences, viruses, phenotype)

Research Gaps and Challenges

  • Characterize determinants of high- vs. low-pathogenicity avian influenza also outside the HA cleavage site Inability/ lack of ease in detecting true reassortment vs. Contamination of sample
  • Characterize zoonotic propensity
  • Limitations for in vivo testing due to animal welfare laws
  • Characterize antigenic properties with respect to vaccine susceptibility
  • Failure to maintain sample authenticity thus inability to study observed outcomes of infection
  • Transparency about human impacts
  • Lack of understanding how genomic reassortment is made exactly

Solution Routes

  • Loss of function experiments both in vitro and in vivo
  • Study virus transmission across interfaces
  • Identification of antibody epitopes important for antigenic drift in swine and poultry species
  • Development of models to predict epitopes based on HA sequence evolution
  • Promotion and adoption of a standard classification scheme (e.g., the global swine clade classification scheme and the H5 clade classification scheme) – and have this classification updated in real time (I.e.: standardized next strain, etc.)

Dependencies

  • Virus isolates
  • Pathogenicity models
  • Interface transmission models
  • Genomic surveillance in multiple hosts and even different sites within host

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands