Influenza roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic test for influenza
Download Influenza-diagnostic-development-roadmap7
Host-pathogen interaction
Dependencies
Next steps
Host-pathogen interaction
Research Question
- Identify the most appropriate target for diagnosis based on the Host pathogen interaction
Research Gaps and Challenges
- Lack of knowledge on the impact of the host’s infection status on the (immune) response
- Virus-host interactions control species-specific pathology.
- Virus-specific host susceptibility, including carrier state.
Solution Routes
- Need to better understand the relevant mechanisms for an effective immune response, role of cross-reactivity and cell-mediated immunity
- Need to understand resistance or susceptibility factors (e.g. intracellular enzymes in different organs, endosomal pH, adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), tumor necrosis factor (TNF) etc.) towards HPAI viruses in different wild (main reservoirs) and domestic bird and mammal species
- Role of microRNAs in modulating pathogenesis
- Host responses for diagnosis of infections, for clues about viral pathogenesis
Dependencies
- Challenge studies that provide foundational information
- Longitudinal studies
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands