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Host-pathogen interaction

Host-pathogen interaction

Research Question

  • Identify the most appropriate target for diagnosis based on the Host pathogen interaction

Research Gaps and Challenges

  • Lack of knowledge on the impact of the host’s infection status on the (immune) response
  • Virus-host interactions control species-specific pathology.
  • Virus-specific host susceptibility, including carrier state.

Solution Routes

  • Need to better understand the relevant mechanisms for an effective immune response, role of cross-reactivity and cell-mediated immunity
  • Need to understand resistance or susceptibility factors (e.g. intracellular enzymes in different organs, endosomal pH, adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), tumor necrosis factor (TNF) etc.) towards HPAI viruses in different wild (main reservoirs) and domestic bird and mammal species
  • Role of microRNAs in modulating pathogenesis
  • Host responses for diagnosis of infections, for clues about viral pathogenesis

Dependencies

  • Challenge studies that provide foundational information
  • Longitudinal studies

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands