Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap
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21481["
2
Naturally attenuated candidates- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
3
Rationally attenuated candidates- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
4
Inactivated vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
5
DNA/RNA- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
6
Subunit vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
7
Vectored vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
1
Vaccine- BDelivery route
8
Attenuated organisms3
Rationally attenuated candidates- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
8
Attenuated organisms9
Adjuvant9
Adjuvant4
Inactivated vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
9
Adjuvant5
DNA/RNA- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
9
Adjuvant6
Subunit vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
10
Expression systems9
Adjuvant11
Vector7
Vectored vaccines- ASafety
- BDelivery route
- CDelivery platform
- DEfficacy in challenge model
12
Identity of protective antigens10
Expression systems12
Identity of protective antigens11
Vector13
Identity of virulence factors8
Attenuated organisms13
Identity of virulence factors12
Identity of protective antigens14
Identity of immunomodulators8
Attenuated organisms14
Identity of immunomodulators12
Identity of protective antigens15
Host responses to natural infection8
Attenuated organisms15
Host responses to natural infection12
Identity of protective antigens16
Identity of mechanisms of protection"] --> 21588["12
Identity of protective antigens17
Host-pathogen interactions"] --> 21590["13
Identity of virulence factors17
Host-pathogen interactions"] --> 21591["14
Identity of immunomodulators17
Host-pathogen interactions"] --> 21645["15
Host responses to natural infection17
Host-pathogen interactions"] --> 21649["16
Identity of mechanisms of protection"] 21680["17
Host-pathogen interactions"] --> 21689["18
Challenge models19
Pathogen genome17
Host-pathogen interactions"] 21690["19
Pathogen genome16
Identity of mechanisms of protection"] linkStyle default stroke-width:1px,stroke:#3bcaf2Lead Summary | Challenges and gap analysis | |
---|---|---|
1B | Delivery route | |
1 | Vaccine | Vaccine |
2D | Efficacy in challenge model | |
2C | Delivery platform | |
2B | Delivery route | |
2A | Safety | |
2 | Naturally attenuated candidates | Naturally attenuated candidates |
3D | Efficacy in challenge model | |
3C | Delivery platform | |
3B | Delivery route | |
3A | Safety | |
3 | Rationally attenuated candidates | Rationally attenuated candidates |
4D | Efficacy in challenge model | |
4C | Delivery platform | |
4B | Delivery route | |
4A | Safety | |
4 | Inactivated vaccines | Inactivated vaccines |
5D | Efficacy in challenge model | |
5C | Delivery platform | |
5B | Delivery route | |
5A | Safety | |
5 | DNA/RNA | DNA/RNA vaccines |
6D | Efficacy in challenge model | |
6C | Delivery platform | |
6B | Delivery route | |
6A | Safety | |
6 | Subunit vaccines | Subunit vaccines |
7D | Efficacy in challenge model | |
7C | Delivery platform | |
7B | Delivery route | |
7A | Safety | |
7 | Vectored vaccines | Vectored vaccines |
8 | Attenuated organisms | Attenuated organisms |
9 | Adjuvant | Adjuvant |
10 | Expression systems | Expression systems |
11 | Vector | Vector |
12 | Identity of protective antigens | Identity of protective antigens |
13 | Identity of virulence factors | Identity of virulence factors |
14 | Identity of immunomodulators | Identity of immunomodulators |
15 | Host responses to natural infection | Host responses to natural infection |
16B | Cell-mediated immunity | Cell-mediated immunity |
16A | Antibody response | Antibody response |
16 | Identity of mechanisms of protection | Identity of mechanisms of protection |
17C | Persistence/clearance | Persistence/clearance |
17B | Replication | Replication |
17A | Entry | Entry |
17 | Host-pathogen interactions | Host-pathogen interactions |
18 | Challenge models | Challenge models |
19 | Pathogen genome | Pathogen genome |