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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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2

Naturally attenuated candidates
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21533["

3

Rationally attenuated candidates
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21551["

4

Inactivated vaccines
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21559["

5

DNA/RNA
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21564["

6

Subunit vaccines
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21569["

7

Vectored vaccines
  • ASafety
  • BDelivery route
  • CDelivery platform
  • DEfficacy in challenge model
"] --> 21480["

1

Vaccine
  • BDelivery route
"] 21576["

8

Attenuated organisms
    "] --> 21533["

    3

    Rationally attenuated candidates
    • ASafety
    • BDelivery route
    • CDelivery platform
    • DEfficacy in challenge model
    "] 21576["

    8

    Attenuated organisms
      "] --> 21580["

      9

      Adjuvant
        "] 21580["

        9

        Adjuvant
          "] --> 21551["

          4

          Inactivated vaccines
          • ASafety
          • BDelivery route
          • CDelivery platform
          • DEfficacy in challenge model
          "] 21580["

          9

          Adjuvant
            "] --> 21559["

            5

            DNA/RNA
            • ASafety
            • BDelivery route
            • CDelivery platform
            • DEfficacy in challenge model
            "] 21580["

            9

            Adjuvant
              "] --> 21564["

              6

              Subunit vaccines
              • ASafety
              • BDelivery route
              • CDelivery platform
              • DEfficacy in challenge model
              "] 21582["

              10

              Expression systems
                "] --> 21580["

                9

                Adjuvant
                  "] 21587["

                  11

                  Vector
                    "] --> 21569["

                    7

                    Vectored vaccines
                    • ASafety
                    • BDelivery route
                    • CDelivery platform
                    • DEfficacy in challenge model
                    "] 21588["

                    12

                    Identity of protective antigens
                      "] --> 21582["

                      10

                      Expression systems
                        "] 21588["

                        12

                        Identity of protective antigens
                          "] --> 21587["

                          11

                          Vector
                            "] 21590["

                            13

                            Identity of virulence factors
                              "] --> 21576["

                              8

                              Attenuated organisms
                                "] 21590["

                                13

                                Identity of virulence factors
                                  "] --> 21588["

                                  12

                                  Identity of protective antigens
                                    "] 21591["

                                    14

                                    Identity of immunomodulators
                                      "] --> 21576["

                                      8

                                      Attenuated organisms
                                        "] 21591["

                                        14

                                        Identity of immunomodulators
                                          "] --> 21588["

                                          12

                                          Identity of protective antigens
                                            "] 21645["

                                            15

                                            Host responses to natural infection
                                              "] --> 21576["

                                              8

                                              Attenuated organisms
                                                "] 21645["

                                                15

                                                Host responses to natural infection
                                                  "] --> 21588["

                                                  12

                                                  Identity of protective antigens
                                                    "] 21649["

                                                    16

                                                    Identity of mechanisms of protection"] --> 21588["

                                                    12

                                                    Identity of protective antigens
                                                      "] 21680["

                                                      17

                                                      Host-pathogen interactions"] --> 21590["

                                                      13

                                                      Identity of virulence factors
                                                        "] 21680["

                                                        17

                                                        Host-pathogen interactions"] --> 21591["

                                                        14

                                                        Identity of immunomodulators
                                                          "] 21680["

                                                          17

                                                          Host-pathogen interactions"] --> 21645["

                                                          15

                                                          Host responses to natural infection
                                                            "] 21680["

                                                            17

                                                            Host-pathogen interactions"] --> 21649["

                                                            16

                                                            Identity of mechanisms of protection"] 21680["

                                                            17

                                                            Host-pathogen interactions"] --> 21689["

                                                            18

                                                            Challenge models
                                                              "] 21690["

                                                              19

                                                              Pathogen genome
                                                                "] --> 21680["

                                                                17

                                                                Host-pathogen interactions"] 21690["

                                                                19

                                                                Pathogen genome
                                                                  "] --> 21649["

                                                                  16

                                                                  Identity of mechanisms of protection"] linkStyle default stroke-width:1px,stroke:#3bcaf2
                                                                  Lead Summary Challenges and gap analysis
                                                                  1B Delivery route
                                                                  1 Vaccine Vaccine
                                                                  2D Efficacy in challenge model
                                                                  2C Delivery platform
                                                                  2B Delivery route
                                                                  2A Safety
                                                                  2 Naturally attenuated candidates Naturally attenuated candidates
                                                                  3D Efficacy in challenge model
                                                                  3C Delivery platform
                                                                  3B Delivery route
                                                                  3A Safety
                                                                  3 Rationally attenuated candidates Rationally attenuated candidates
                                                                  4D Efficacy in challenge model
                                                                  4C Delivery platform
                                                                  4B Delivery route
                                                                  4A Safety
                                                                  4 Inactivated vaccines Inactivated vaccines
                                                                  5D Efficacy in challenge model
                                                                  5C Delivery platform
                                                                  5B Delivery route
                                                                  5A Safety
                                                                  5 DNA/RNA DNA/RNA vaccines
                                                                  6D Efficacy in challenge model
                                                                  6C Delivery platform
                                                                  6B Delivery route
                                                                  6A Safety
                                                                  6 Subunit vaccines Subunit vaccines
                                                                  7D Efficacy in challenge model
                                                                  7C Delivery platform
                                                                  7B Delivery route
                                                                  7A Safety
                                                                  7 Vectored vaccines Vectored vaccines
                                                                  8 Attenuated organisms Attenuated organisms
                                                                  9 Adjuvant Adjuvant
                                                                  10 Expression systems Expression systems
                                                                  11 Vector Vector
                                                                  12 Identity of protective antigens Identity of protective antigens
                                                                  13 Identity of virulence factors Identity of virulence factors
                                                                  14 Identity of immunomodulators Identity of immunomodulators
                                                                  15 Host responses to natural infection Host responses to natural infection
                                                                  16B Cell-mediated immunity Cell-mediated immunity
                                                                  16A Antibody response Antibody response
                                                                  16 Identity of mechanisms of protection Identity of mechanisms of protection
                                                                  17C Persistence/clearance Persistence/clearance
                                                                  17B Replication Replication
                                                                  17A Entry Entry
                                                                  17 Host-pathogen interactions Host-pathogen interactions
                                                                  18 Challenge models Challenge models
                                                                  19 Pathogen genome Pathogen genome