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Roadmap for the development of candidate vaccines for influenza

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Naturally attenuated candidates

Next steps

Naturally attenuated candidates

Research Question

  • Develop safe live virus Influenza vaccines – without risk of reassortment.
  • Amenable for mass vaccination – control

Research Gaps and Challenges

  • Develop vaccines easy to administer that induce strong mucosal immunity able to block shedding, and prevent infection and transmission of LPAIV and HPAIV
  • Regulatory issues regarding attenuated vaccine usage due to safety for public health (possible reversion of virulence)
  • Risk of reversion to virulence and/or recombination
  • Application may depend on target species swine, equine versus avian species
  • Cost of vaccine for each species

Solution Routes

  • Solution for blocking reversion of virulence and reassortment

State Of the Art

  • No incentive for industry to invest in research on Al attenuated vaccines as current regulation do not allow its use

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands