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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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3

Rationally attenuated candidates

Dependencies

Next steps

Rationally attenuated candidates

Research Question

  • Develop safe live rationally attenuated vaccine candidate

Research Gaps and Challenges

  • Safety for VPH- vaccines without risk of reassortment
  • Regulatory issues regarding vaccine usage
  • No incentive for industry to invest in Al vaccines that can’t be used

Solution Routes

  • Mechanisms to reduce shedding (route, type of immune response)
  • Cold-adapted LAIVs vaccines?

State Of the Art

US Patent No. 11,214,799 B2 (Jan 4th 2022) entitled ‘HA-specific
influenza virus attenuated vaccine comprising mutations in segment 7
and uses therefor’; D.R. Kapczynski, P. Digard, L. Vervelde and D.
Suarez

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Impact of host age on viral and bacterial communities in a waterbird population.

Planned Completion date 01/11/2022

Participating Country(s):

NetherlandsIconNetherlands