Roadmap for the development of candidate vaccines for influenza

Download Influenza-vaccine-development-roadmap

Rationally attenuated candidates

visit roadmap

Dependencies

8 Attenuated organisms

Next steps

1 Vaccine
1B Delivery route

Rationally attenuated candidates

Research Question

Develop safe live rationally attenuated vaccine candidate

Research Gaps and Challenges

Safety for VPH- vaccines without risk of reassortment
Regulatory issues regarding vaccine usage
No incentive for industry to invest in Al vaccines that can’t be used

Solution Routes

Mechanisms to reduce shedding (route, type of immune response)
Cold-adapted LAIVs vaccines?

State Of the Art

US Patent No. 11,214,799 B2 (Jan 4th 2022) entitled ‘HA-specific
influenza virus attenuated vaccine comprising mutations in segment 7
and uses therefor’; D.R. Kapczynski, P. Digard, L. Vervelde and D.
Suarez

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

Netherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024