Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap3
Rationally attenuated candidates
Rationally attenuated candidates
Research Question
- Develop safe live rationally attenuated vaccine candidate
Research Gaps and Challenges
- Safety for VPH- vaccines without risk of reassortment
- Regulatory issues regarding vaccine usage
- No incentive for industry to invest in Al vaccines that can’t be used
Solution Routes
- Mechanisms to reduce shedding (route, type of immune response)
- Cold-adapted LAIVs vaccines?
State Of the Art
US Patent No. 11,214,799 B2 (Jan 4th 2022) entitled ‘HA-specific
influenza virus attenuated vaccine comprising mutations in segment 7
and uses therefor’; D.R. Kapczynski, P. Digard, L. Vervelde and D.
Suarez
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Participating Country(s):
Netherlands