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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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4

Inactivated vaccines

Dependencies

Next steps

Inactivated vaccines

Research Question

  • Fast production of highly immunogenic inactivated vaccines for novel
    strains

Research Gaps and Challenges

  • Low immune response
  • Low speed of production for novel strains
  • Rapid production of vaccine due to the limitation of virus growth on
    eggs
  • Inactivated vaccines do not allow for mass application and need to
    match the circulating strain to confer reasonable protection

Solution Routes

  • Development of a suitable tissue culture system for production
  • Strategies to increase mucosal immune responses after inactivated
    vaccines
  • Novel/improved adjuvants
  • Ability to overcome Maternally Derived Antibodies (MDA) interference.
  • Build on improvement in humans research

Dependencies

  • Identification of best vaccination strategies (Mucosal vs systemic protection vaccine for the whole year or specific period of time or season?)

State Of the Art

  • Mostly egg based inactivated vaccines. Egg manufacturing platform is
    costly, and supply is limited
  • Currently the inactivated vaccine provides suboptimal immunity in birds with maternally derived antibodies (MDA), but birds are vaccinated in ovo and day old in the hatchery

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands