Home Influenza [Adjuvant] Adjuvant
Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

Download Influenza-vaccine-development-roadmap

9

Adjuvant

Dependencies

Next steps

  • 4 Inactivated vaccines
  • 4A Safety
  • 4B Delivery route
  • 4C Delivery platform
  • 4D Efficacy in challenge model
  • 5 DNA/RNA
  • 5A Safety
  • 5B Delivery route
  • 5C Delivery platform
  • 5D Efficacy in challenge model
  • 6 Subunit vaccines
  • 6A Safety
  • 6B Delivery route
  • 6C Delivery platform
  • 6D Efficacy in challenge model
Adjuvant

Research Question

  • New adjuvant stimulating durable immune response and no adverse reaction for the animal

Research Gaps and Challenges

  • Promote an appropriate immune response with reduced amount of
    antigen
  • Withdrawal time of adjuvant in livestock production systems
  • Adjuvants to improve/broad responses using vectors or attenuated
    organisms
  • Stability, safety and immunogenicity at a feasible cost
  • Adjuvants are primarily targeted to antibody response: harder to
    measure mucosal or cellular response and this limits field of application

Solution Routes

  • Better understanding of the mechanisms and immune – system – wide effects of new and existing adjuvants to enable rational design of improved vaccines with rapid onset of broadly – protective humoral, cellular and innate immunity
  • Development of vaccines/adjuvants to induce broad/universal clinical cross-protection
  • Mucosal adjuvants for IN application in swine/equine? and spray in
    poultry
  • Studies to establish the most suitable molecular adjuvants for nucleic acid-based vaccines that could be used in food producing species

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Impact of host age on viral and bacterial communities in a waterbird population.

Planned Completion date 01/11/2022

Participating Country(s):

NetherlandsIconNetherlands