Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap9
Adjuvant
Dependencies
Next steps
- 4 Inactivated vaccines
- 4A Safety
- 4B Delivery route
- 4C Delivery platform
- 4D Efficacy in challenge model
- 5 DNA/RNA
- 5A Safety
- 5B Delivery route
- 5C Delivery platform
- 5D Efficacy in challenge model
- 6 Subunit vaccines
- 6A Safety
- 6B Delivery route
- 6C Delivery platform
- 6D Efficacy in challenge model
Adjuvant
Research Question
- New adjuvant stimulating durable immune response and no adverse reaction for the animal
Research Gaps and Challenges
- Promote an appropriate immune response with reduced amount of
antigen - Withdrawal time of adjuvant in livestock production systems
- Adjuvants to improve/broad responses using vectors or attenuated
organisms - Stability, safety and immunogenicity at a feasible cost
- Adjuvants are primarily targeted to antibody response: harder to
measure mucosal or cellular response and this limits field of application
Solution Routes
- Better understanding of the mechanisms and immune – system – wide effects of new and existing adjuvants to enable rational design of improved vaccines with rapid onset of broadly – protective humoral, cellular and innate immunity
- Development of vaccines/adjuvants to induce broad/universal clinical cross-protection
- Mucosal adjuvants for IN application in swine/equine? and spray in
poultry - Studies to establish the most suitable molecular adjuvants for nucleic acid-based vaccines that could be used in food producing species
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Impact of host age on viral and bacterial communities in a waterbird population.
Planned Completion date 01/11/2022
Participating Country(s):
Netherlands