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Influenza roadmap:
Vaccines

Roadmap for the development of candidate vaccines for influenza

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10

Expression systems

Expression systems

Research Question

  • Fast and cost feasible protein expression systems

Research Gaps and Challenges

  • Other antigens/factors than HA that can improve vaccine effectiveness
  • HA are not all created equal, some are poor immunogens
  • Speed of expression system
  • Cost
  • Scale up-capacity

Solution Routes

  • Re-engineering of existing systems
  • Multi-omics or a system-based biological approach may improve the quality of the expressed protein, such as creating a molecule with a better glycosylation profile
  • Identification of novel expression system

State Of the Art

  • Current expression systems are mostly focused on HA

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands