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Influenza roadmap:
Control Strategies

Roadmap for the development of disease control strategies for influenza

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Therapeutics

Therapeutics

Research Question

  • To develop effective and affordable therapeutics for influenza viruses for targeted species
  • Develop strategies for therapeutics use

Research Gaps and Challenges

  • Risk of the emergence and spread of resistance
  • Identify appropriate uses of antivirals in animal
  • Residuals in products and environment (withdrawal time and MRL)
  • Cost of therapeutics for animal production systems
  • Preservation of therapeutics for human use and possible high value companion animals to reduce antiviral resistance development
  • Need to have clear definitions on how to determine when a flock/bird is negative
  • Is there a need/market for therapeutics in controlling outbreaks?

Solution Routes

  • Development of flu antivirals (particularly for horses and companion animals?)—reduce virus shedding while avoiding spread of drug resistance esp. to human/swine flu
  • Demonstrate safety for animal, human and environment of new therapeutics, defining
  • Withdrawal period and MRL
  • Explore approaches that might overcome resistance issues like siRNA
  • Define how to use therapeutics in control: use and depopulate approach or use in animals that don’t enter the food chain: Zoo birds,
    endangered species, hi value breeders, etc.
  • Decision tool or decision matrix to guide practitioners should be made
    available
  • Establish if therapeutics have been implemented/used regionally

Dependencies

  • Involve public health side here

State Of the Art

  • Currently therapeutics can’t be used in production animals as stamping out is applied for biosafety reasons

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands