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Influenza roadmap:
Control Strategies

Roadmap for the development of disease control strategies for influenza

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Active Infection

Active Infection

Research Question

  • Duration (and quantification?) of infectious windows for various subtypes
  • Windows of susceptibility (species, physiological status, age, presence of MDAs, etc) and shedding

Research Gaps and Challenges

  • Effect of mutations at receptor binding site on viral replication and bird/mammalian species adaptation
  • Determinants of viral shedding from respiratory vs. intestinal tracts
  • Role of unregulated cytokine expression in production of vaccine associated enhanced respiratory disease of swine (important also for
    other different species and virus strains)

Solution Routes

  • Comparative studies of pathogenesis with different influenza viruses in the swine host
  • Virus shedding patterns at the individual and flock level and age group level
  • Replication and transmission efficiency studies: compare similar studies e.g. using Mexican lineage H5N2 LPAIV and / or Asian H9N2
  • Studies on the state of active infection in hosts with varying levels of immunity

Dependencies

  • Challenge studies with various hosts/ages/immunity/viral strains

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands