Home Influenza [Pathogen genome] Pathogen genome
Influenza roadmap:
Control Strategies

Roadmap for the development of disease control strategies for influenza

Download Influenza-control-development-roadmap

14

Pathogen genome

Pathogen genome

Research Question

  • Understand the influenza genome (pathogenicity, immune suppression, adaptation to new species, ecology, impact of interventions such as vaccination on evolution, etc.)
  • What allows LPAIV to switch to HPAIV in H5 and H7 and not in other subtypes
  • What makes the AI to change into a strain dangerous for humans

Research Gaps and Challenges

  • Reassortment and continuing spread of H5N8 (goose Guandong lineage H5 viruses)
  • Rate of genetic change and factors affecting
  • Mechanisms of gene reassortment between virus subtypes

Solution Routes

  • Continuing development of NGS-based whole genome sequencing
  • Effective deployment of 3rd -gen sequencing technologies for both wet- and dry-lab protocols, allowing point-of-incidence analysis
  • Maps of virulence signatures for artificial intelligence / machine learning algorithms that can better link genotype to phenotype
  • Molecular signatures in viruses associated with improved environmental stability (effect of ammonia , temperature ) and vaccination
  • Sequences and metadata from viruses in a broad variety of hosts and under varied conditions
  • Sequences from IAV events in which various viral phenotypes are suspected (aerosol transmission, survival in the environment,
    multi-species infection, etc.)

Dependencies

  • Improved data sharing of sequences – especially in real time
  • Mechanisms of intra-host virus evolution

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands