Roadmap for the development of diagnostic test for bTB

What are we trying to achieve and why? What is the problem we are trying to solve?

As indicated by epidemiological studies of human TB, there must exist animals that are exposed to M bovis in herds but do resist/clear infection without signs of exposition (TST neg) . We need to understand the innate immune system of these individuals

What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?

We need to define the roles of different cells of the immune system in cattle (alveolar macrophages, neutrophils and others) in uptake and clearance of the pathogen)

What approaches could/should be taken to address the research question?

We need to embrace the One Health approach and work together with human TB specialists

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures