Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapB
Cell-mediated immunity
Cell-mediated immunity
Research Question
- Identify the role of cellular immune response to protect from infection
Research Gaps and Challenges
- Understand the role (and duration) of the cellular immune response in protection and in the pathogenesis of different influenza strains
- Understanding of the cellular immune response of chickens to HPAI and its significance during infection
Solution Routes
- Role of cell mediated immunity in protection following infection in wild birds versus poultry, and in particular its role in determining transmission
- Characterization of the post-vaccination adaptive cellular immune response in swine
- Passive transfer studies
- Study on LPAI capacity to replicate within birds in extra respiratory and extra GI sites and the relative alteration of immunity response
- Improved diagnostic tools to measure the cellular immune response that allows us to predict protection
Interferon type I and type II needs to be measure - Which phenotype of immune cells respond to infection of vaccines
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands