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Roadmap for the development of candidate vaccines for influenza

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Challenge models

Challenge models

Research Question

  • Need standardised challenge models to compare different vaccines and approaches to vaccination (including chicken, ducks and turkeys)
  • Assess vaccine performance under field conditions to validate laboratory models of vaccination

Research Gaps and Challenges

  • Reproducibility of studies of virulence, transmission, innate and adaptive immune responses – Credibility of research enterprise
  • Equine model is expensive
  • Identification of factors that can affect the effectiveness of AIV vaccination
  • Different breeds of chickens (Broilers Vs Layers and breeder respond differently

Solution Routes

  • Conduct comparative vaccine efficacy studies in avian species other than egg – type chickens, including turkeys, broilers and domestic ducks
  • New models for equine flu
  • Data algorithm for vaccine implementation in swine
  • In vitro, ex vivo and different animal challenge models
  • Development of standardized challenge models relating to challenge dose and route of administration for different species

Dependencies

  • Establish parameters that suggest vaccine success
  • Understanding host-pathogen interactions in these systems is very important
  • Understand changes in genome that can effect virus
  • Integrative studies that involve surveillance, molecular epidemiology, animal studies and reverse genetics ( DURC study – how do we make it
    happen?) (see disease control roadmap)

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands