Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmap18
Challenge models
Challenge models
Research Question
- Need standardised challenge models to compare different vaccines and approaches to vaccination (including chicken, ducks and turkeys)
- Assess vaccine performance under field conditions to validate laboratory models of vaccination
Research Gaps and Challenges
- Reproducibility of studies of virulence, transmission, innate and adaptive immune responses – Credibility of research enterprise
- Equine model is expensive
- Identification of factors that can affect the effectiveness of AIV vaccination
- Different breeds of chickens (Broilers Vs Layers and breeder respond differently
Solution Routes
- Conduct comparative vaccine efficacy studies in avian species other than egg – type chickens, including turkeys, broilers and domestic ducks
- New models for equine flu
- Data algorithm for vaccine implementation in swine
- In vitro, ex vivo and different animal challenge models
- Development of standardized challenge models relating to challenge dose and route of administration for different species
Dependencies
- Establish parameters that suggest vaccine success
- Understanding host-pathogen interactions in these systems is very important
- Understand changes in genome that can effect virus
- Integrative studies that involve surveillance, molecular epidemiology, animal studies and reverse genetics ( DURC study – how do we make it
happen?) (see disease control roadmap)
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Intervention Strategies to Control Endemic and New and Emerging Influenza A Virus Infections in Swine
Planned Completion date 04/10/2026
Source Countries:
United States