Roadmap for the development of candidate vaccine for bTB

What are we trying to achieve and why? What is the problem we are trying to solve?

BCG needs to be validated in relation to its efficacy in controlling bovine TB for a) its immediate deployment and b)
to serve as a base-line against which other vaccines are compared.

What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?

What approaches could/should be taken to address the research question?

• Establish the most effective vaccination regimen – dose, number of vaccinations, route of administration and optimal age for administration.
• Vaccination, monitoring of immune responses and experimental challenge
• Field trials

What else needs to be done before we can solve this need?

• Agreed challenge models
• Correlates of protection

Existing knowledge including successes and failures