Bovine Tuberculosis (bTB) roadmap:
Vaccines
Roadmap for the development of candidate vaccine for bTB
Download bTB-Vaccine-Roadmap9
Adjuvant
Dependencies
- 10 Expression system
- 12 Identity of protective antigens
- 8 Attenuated organisms
Next steps
- 4 Inactivated Vaccines
- 4A Safety
- 4B Delivery route
- 4C Delivery platform
- 4D Efficacy in challenge model
- 5 DNA/RNA vaccines
- 5A Safety
- 5B Delivery route
- 5C Delivery platform
- 5D Efficacy in challenge model
- 6 Subunit vaccines
- 6A Safety
- 6B Delivery route
- 6C Delivery platform
- 6D Efficacy in challenge model
Identifying suitable delivery systems for subunit vaccine candidates and DNA vaccine candidates
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Generation of an optimal immune response to the various sub-unit candidates and DNA candidates
Research Gaps and Challenges
What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?
Solution Routes
What approaches could/should be taken to address the research question?
- Immune response to antigens delivered on Nanoparticles
- Immune response following inclusion of various adjuvants with the candidate vaccines
- Molecular adjuvants for DNA candidates
Dependencies
What else needs to be done before we can solve this need?
Identity of protective mechanisms
State Of the Art
Existing knowledge including successes and failures
Projects
What activities are planned or underway?
Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis.
Planned Completion date 15/08/2023
Participating Country(s):
Netherlands
Inferring Bovine Tuberculosis Transmission Between Cattle and Badger via Environment and Risk mapping
Planned Completion date 01/01/2023
Participating Country(s):
Netherlands