African Swine Fever roadmap:
Vaccines
Roadmap for the development of a candidate vaccine for ASF
Download ASF Vaccine Roadmap8
Attenuated organisms
Dependencies
Next steps
- 3 Rationally attenuated candidates
- 3A Safety
- 3B Delivery route
- 3C Delivery platform
- 3D Efficacy in challenge model
- 9 Adjuvant
Attenuated organisms
Research Question
- To generate organisms that are less virulent in terms of pathological changes that they cause and/or their ability to modulate the host’s immune responses – rationally
attenuated vaccine
Research Gaps and Challenges
- Ensure the organisms are stable and can be produced in cell
culture - Ensure the organisms can still generate a protective response
- Ensure the organisms give protection against heterologous challenge
Solution Routes
- Identify ASFV genes involved in virulence and in evasion of the host’s immune response.
Generate and characterise a range of rationally attenuated organisms - Immune response to the attenuated organisms
Dependencies
- Identify virulence factors and their genes
- Identify immunomodulators
- Ensure ability to give cross protection against heterologous challenge
Projects
What activities are planned or underway?
Africa's Long Depression: The Growth and Debt Crises of 1975-2000
Planned Completion date 01/03/2027
Participating Country(s):
United Kingdom
Mechanistic and Pathway Analysis of Animal Influenza Virus cross-species transmission by constructing genotype and phenotype networks
Planned Completion date 01/02/2028
Participating Country(s):
United Kingdom