Roadmap for Phage technologies

What are we trying to achieve and why? What is the problem we are trying to solve?

Can we use phage capsids to deliver material toxic to bacteria?

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

Technological challenges – capsid construction and encapsulating delivery material.
Timely administration of phage for therapy.

What approaches could/should be taken to address the research question?

Delivery material can be chemically conjugated to capsid surface, if ‘natural’’ phage is identified.

What else needs to be done before we can solve this need?

Prompt diagnosis.

Existing knowledge including successes and failures

See work of George Lomonossoff at John Innes.