Roadmap for Immunomodulators

What are we trying to achieve and why? What is the problem we are trying to solve?

Investigating epithelial cells metabolism and proliferation.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

Identify products that improve epithelial cells activities in vitro and in vivo, under normal or stress conditions (oxidative imbalance, toxins, infections, general mucosal damage, undernourished animals, etc).

What approaches could/should be taken to address the research question?

Identify and classify products that can stimulate several/different metabolic pathways and proliferative phases of epithelial cells, particularly at small intestine.

What else needs to be done before we can solve this need?

Investigating the action with cell lines.
Characterising the impact on intestinal epithelial cells and overall epithelium physiology in healthy and challenged animals.
Investigating the action with cell lines or organoids.
Role of nutrients (e.g. Vit A).

Existing knowledge including successes and failures