Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v14
Development of a killed/inactivated Brucella vaccine
Dependencies
Next steps
Inactivated Vaccines
Research Question
- The development of an effective killed vaccine that can be used in pregnant animals.
Research Gaps and Challenges
- Having the protective response involving both Abs and CTC
Solution Routes
- Generation of a range of recombinant organisms expressing protective Antigens from a range of Brucella species.
- Monitoring the immune response following immunisation with the various candidates.
- Challenge experiments with the various vaccine candidates.
Dependencies
- Identifying a combination of antigens for expression by a GM strain of Brucella
- The availability of suitable adjuvants to stimulate strong CTC and Ab responses.
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom