Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v15
Development of a DNA vaccine for Brucellosis
Dependencies
Next steps
DNA/RNA Vaccines
Research Question
- The development of an effective DNA vaccine for use on its own or in combination with other Brucella vaccines in a prime-boost combination.
Solution Routes
- Establishing the immune responses following immunisation with DNA coding for various protective antigens.
- Challenge experiments involving animals vaccinated with DNA fragments identified from experiments looking at the immune responses.
Dependencies
- Identifying a combination of protective antigens the genes for which could form part of a DNA vaccine
- Identifying suitable molecular adjuvants to stimulate strong cell-mediated immune responses
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom