Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v17
Development of a vectored Brucella vaccine
Vectored Vaccines
Research Question
- The development of an effective novel vaccine.
- A replicating organism expressing the correct combination of Ags is more likely to generate the required type of immune response but as it would have a restricted combination of Brucella antigens it is unlikely to give false positive test results in the standard skin test
Research Gaps and Challenges
- Generating a strong protective immune response
- Preventing the development of immune responses to the vector
Solution Routes
- Establishing the immune responses to Brucella antigens following vaccination with the vectored vaccine.
- Establishing the immune responses to the vector
- Challenge experiments involving animals vaccinated with candidate organisms.
Dependencies
- Identifying a combination of antigens for expression by a vector or a common single Ag to which immune responses are normally suppressed
- Identifying a suitable vector
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom