Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v113
Identification of the Brucella virulence factors that contribute to disease pathology
Dependencies
- 17 Host Pathogen interaction in Brucellosis infection
- 17A Entry
- 17B Replication
- 17C Persistence/Clearance
Next steps
Identity of Virulence Factor
Research Question
- Identifying and removal of the factors contributing to pathological changes are essential for generating rationally attenuated vaccines
Research Gaps and Challenges
- Immunogenicity may be linked to virulence
Solution Routes
- Generation of a range of knock-out bacteria where putative virulence factors have been removed and their use in experimental infections
Dependencies
- Improved understanding of Brucella – macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Investigating mechanisms of gallbladder persistence in Salmonella
Planned Completion date
Participating Country(s):
United Kingdom