Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v114
To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections
Dependencies
- 17 Host Pathogen interaction in Brucellosis infection
- 17A Entry
- 17B Replication
- 17C Persistence/Clearance
Next steps
Identity of immunomodulators
Research Question
- Pathogens manipulate the immune responses of the host in an attempt to survive. Establishing how the various Brucella species manipulate the host’s immune response will allow these factors to be removed and thus allow the hosts immune system to react to the organism in a different way, possibly enhancing protection
Research Gaps and Challenges
- Identifying deleterious immunomodulatory factors from ones that may be beneficial.
Solution Routes
- Generation of a range of knock-out Brucella organisms where the genes for various immunomodulatory factors or other stealth mechanisms have been removed and their use in experimental infections.
Dependencies
- Improved understanding of Brucella-macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom