Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v117
Host Pathogen interaction in Brucellosis infection
Dependencies
- 18 Pathogen Genome
Next steps
- 16 To identify protective mechanisms in Brucella-infected animals
- 16A Antibody Response
- 16B Cell Mediated Immunity
- 15 Host Responses to Natural Infection
- 14 To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections
- 13 Identification of the Brucella virulence factors that contribute to disease pathology
Host-Pathogen Interactions
Research Question
- To gain an improved understanding of how Brucella species enter, replicate and survive in and are released from infected cells
Research Gaps and Challenges
- Brucella species infect macrophages which are an important contributor to the immune response so establishing how the bacterium interacts with macrophages is central to identifying the protective mechanisms and how the virus evades them.
Solution Routes
- Brucella species and macrophage gene expression(transcriptome/RNA sequence data) in different in vivo environments (macrophages from naïve and immune hosts and in carrier animals)
- Compare response where macrophages are infected with different Brucella species and strains, including s19, Rev 1 and RB51 looking at gene responses of the macrophage and the bacterium.
- Comparison of the macrophage-bacteria response following clearance, in latency/carrier states and in active infections.
- Identify disease stage biomarkers
Dependencies
- The genome sequence of the various Brucella species, including s19, Rev 1 and RB51.
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Investigating mechanisms of gallbladder persistence in Salmonella
Planned Completion date
Participating Country(s):
United Kingdom