Coronaviruses roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic tests for coronaviruses
Download 202410 Draft Coronavirus Diagnostic Development_Final5
Host response
Dependencies
Next steps
Host response
Research Question
- Identify a measurable host response and generation of positive control reagents
Research Gaps and Challenges
- Understand how well SPF animals mimic natural infections (e.g. Consideration for inbred vs outbred lab animals)
- Characterisation of natural history/growth kinetics of CoVs in appropriate animal models – comparison of acute vs established or historic infections
- Detection of current and previous infections
- How to select the best hosts to focus on. Is the host that favours coronavirus recombination the best one?
Solution Routes
- Longitudinal studies on animals naturally exposed to different coronaviruses
- Development of suitable detection platforms for different host responses
Dependencies
- Development of in vitro models (e.g. organoid) to propagate infectious material for in vivo animal studies
- Animal models and growth kinetics in each specific animal model species
- Detection platform in either a species-dependent or -independent manner
Projects
What activities are planned or underway?
Differential susceptibility of SARS-CoV-2 in animals : Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation
Planned Completion date 26/07/2021
Participating Country(s):
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Participating Country(s):
Europe