Home Coronaviruses [Host response] Host response
Coronaviruses roadmap:
Diagnostic Tests

Roadmap for the development of diagnostic tests for coronaviruses

Download 202410 Draft Coronavirus Diagnostic Development_Final

5

Host response

Host response

Research Question

  • Identify a measurable host response and generation of positive control reagents

Research Gaps and Challenges

  • Understand how well SPF animals mimic natural infections (e.g. Consideration for inbred vs outbred lab animals)
  • Characterisation of natural history/growth kinetics of CoVs in appropriate animal models – comparison of acute vs established or historic infections
  • Detection of current and previous infections
  • How to select the best hosts to focus on. Is the host that favours coronavirus recombination the best one?

Solution Routes

  • Longitudinal studies on animals naturally exposed to different coronaviruses
  • Development of suitable detection platforms for different host responses

Dependencies

  • Development of in vitro models (e.g. organoid) to propagate infectious material for in vivo animal studies
  • Animal models and growth kinetics in each specific animal model species
  • Detection platform in either a species-dependent or -independent manner