Coronaviruses roadmap:
Control Strategies
Roadmap for the development of disease control strategies for coronaviruses
Download 202410 Draft Coronavirus Disease control research roadmap Final14
Pathogen genome
Pathogen genome
Research Question
- Understanding which genome changes increase pathogenicity and cross-species jump
Research Gaps and Challenges
- Little is known on pathogenesis of bat viruses
- Unknown genomic changes that can increase pathogenicity and cross-species jump
Solution Routes
- Identify genomic targets that are highly conserved and specific to the pathogenic strains
- Reverse genetic studies in-vivo and in vitro infection assays
Dependencies
- Facilitating data sharing and interoperability
- Surveillance strategies
- New technologies for multiplex detection and sequencing strategies
- Continued improvement of whole genome sequencing. technologies (e.g. high-throughput sequencing technologies) for genomic surveillance
Projects
What activities are planned or underway?
Differential susceptibility of SARS-CoV-2 in animals : Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation
Planned Completion date 26/07/2021
Participating Country(s):
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Participating Country(s):
Europe