Home ‹ Porcine Reproductive & Respiratory Syndrome ‹ [Adjuvant] Identifying suitable delivery systems for subunit and inactivated whole virus vaccine candidates
Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines

Roadmap for development of a candidate vaccine for PRRSV

Download PRRSV Vaccine Roadmap

9

Adjuvant

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Dependencies

Next steps

  • 4 Inactivated vaccines
  • 4A Safety
  • 4B Delivery route
  • 4C Delivery platform
  • 4D Efficacy in challenge model
  • 5 DNA/RNA vaccines
  • 5A Safety
  • 5B Delivery route
  • 5C Delivery platform
  • 5D Efficacy in challenge model
  • 6 Subunit vaccines
  • 6A Safety
  • 6B Delivery route
  • 6C Delivery platform
  • 6D Efficacy in challenge model
Identifying suitable delivery systems for subunit and inactivated whole virus vaccine candidates

Research Question

  • Generate an optimal immune response to the various vaccine candidates resulting in sterile immunity to wild type virus

Research Gaps and Challenges

  • Generating both a strong VN Ab and a CTC response

Solution Routes

  • Immune response to antigens delivered on nanoparticles
  • Immune response following inclusion of various adjuvants with the candidate vaccines

Dependencies

  • Identity of protective antigens

Projects

What activities are planned or underway?

Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants

Planned Completion date 01/02/2021

Source Countries:

NetherlandsIconNetherlands

Additional file 1 of Analysis of ORF5 sequences of Porcine Reproductive and Respiratory Syndrome virus (PRRSV) circulating within swine farms in Costa Rica

Planned Completion date 01/01/2021

Source Countries:

NetherlandsIconNetherlands