Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap1
Vaccine
An improved multivalent PRRSV vaccine preventing disease, virus transmission and carrier state in vaccinated animals
Research Question
- Protection against disease caused by the various virus strains
- Sterile immunity
- Prevent vaccine virus contributing to evolution of field isolates
- Virus eradication from a herd
Research Gaps and Challenges
- Cross-protection against the various isolates
- Attenuated live viruses can contribute to virus evolution
- Generation of both a CTC and VN response
- The dominant immunogens may not be protective
Solution Routes
- Establish protection levels with various candidate vaccine options, including priming with one vaccine and boosting with a different vaccine
- Establish if pig genetics influences responses
- Incorporate the candidate vaccine in a vaccine platform covering a number of diseases
- The development of farm strain-specific vaccines (autologous vaccines)
Dependencies
- Development of cross protective/multivalent killed vaccine
- Development of a cross protective/multivalent vectored vaccine
- Development of a subunit vaccine
- Development of an attenuated vaccine that does not persist or is excreted
Projects
What activities are planned or underway?
Peer-led service delivery model to increase HIV prevention and contraception in pregnant and lactating adolescent girls and young women in Zimbabwe
Planned Completion date 01/03/2028
Participating Country(s):
United Kingdom
Iron and Manganese Impacts on the Future of Southern Ocean Ecosystems (Iron-Man)
Planned Completion date 01/05/2029
Participating Country(s):
United Kingdom