Roadmap for the development of candidate vaccine for bTB
Download bTB-Vaccine-Roadmap8
Attenuated organisms
Dependencies
Next steps
- 3 Rationally attenuated candidates
- 3A Safety
- 3B Delivery route
- 3C Delivery platform
- 3D Efficacy in challenge model
- 9 Adjuvant
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
Rational attenuation of M bovis by removing virulence genes so that it protects against infection but doesn’t cause disease.
Research Gaps and Challenges
What are the scientific and technological challenges
(knowledge gaps needing to be addressed)?
That the GM bacterium is stable and can be grown in culture
Solution Routes
What approaches could/should be taken to address the research question?
Removal of one or more virulence genes and establishing viability and virulence and immunogenicity of the resulting
organism
Dependencies
What else needs to be done before we can solve this need?
- Identity of virulence factors
- Identity of immunomodulatory factors in the bacterium
- Identity of immunogens responsible for PPD skin sensitisation
State Of the Art
Existing knowledge including successes and failures
Projects
What activities are planned or underway?
Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis.
Planned Completion date 15/08/2023
Netherlands
Inferring Bovine Tuberculosis Transmission Between Cattle and Badger via Environment and Risk mapping
Planned Completion date 01/01/2023
Netherlands