Home ‹ Brucellosis ‹ [Rationally Attenuated Candidates] Development of a novel Brucellosis attenuated vaccine allowing DIVA
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Vaccines

Roadmap for development of a candidate vaccine for Brucella

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Development of a novel Brucellosis attenuated vaccine allowing DIVA

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Dependencies

Next steps

Rationally Attenuated Candidates

Research Question

  • The development of a novel attenuated vaccine that gives better protection and/or improved safety than current vaccines and allows differentiation of infected and vaccinated animals

Research Gaps and Challenges

  • Which strain of the various Brucella species to start with

Solution Routes

  • Establishing the immune responses to genetically modifies Brucella organisms
  • Challenge experiments involving animals vaccinated with candidate organisms

Dependencies

  • The generation of GM organisms where the genes for selected virulence factors have been removed

Projects

What activities are planned or underway?

Estimates of disease burden caused by foodborne pathogens in contaminated dairy products in Rwanda.

Planned Completion date 06/04/2023

Source Countries:

NetherlandsIconNetherlands

An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania

Planned Completion date 14/07/2021

Source Countries:

NetherlandsIconNetherlands