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Vaccines

Roadmap for development of a candidate vaccine for Brucella

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Development of a novel Brucellosis attenuated vaccine allowing DIVA

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Dependencies

Next steps

Rationally Attenuated Candidates

Research Question

  • The development of a novel attenuated vaccine that gives better protection and/or improved safety than current vaccines and allows differentiation of infected and vaccinated animals

Research Gaps and Challenges

  • Which strain of the various Brucella species to start with

Solution Routes

  • Establishing the immune responses to genetically modifies Brucella organisms
  • Challenge experiments involving animals vaccinated with candidate organisms

Dependencies

  • The generation of GM organisms where the genes for selected virulence factors have been removed

Projects

What activities are planned or underway?

EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis

Planned Completion date

Participating Country(s):

United KingdomIconUnited Kingdom

Milk proteins in bovine mastitis: biomarkers of disease and biological function

Planned Completion date

Participating Country(s):

United KingdomIconUnited Kingdom