Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v11
Brucella (B. abortus; B. melitensis; B. suis) vaccines
Dependencies
- 2 Brucella (B. abortus; B. melitensis; B. suis) vaccines
- 2A Safety
- 2B Delivery Route
- 2C Delivery Platform
- 2D Efficacy in Challenge Model
- 3 Development of a novel Brucellosis attenuated vaccine allowing DIVA
- 3A Safety
- 3B Delivery Route
- 3C Delivery Platform
- 3D Efficacy in Challenge Model
- 4 Development of a killed/inactivated Brucella vaccine
- 4A Safety
- 4B Delivery Route
- 4C Delivery Platform
- 4D Efficacy in Challenge Model
- 5 Development of a DNA vaccine for Brucellosis
- 5A Safety
- 5B Delivery Route
- 5C Delivery Platform
- 5D Efficacy in Challenge Model
- 6 Development of a Brucella subunit vaccine
- 6A Safety
- 6B Delivery Route
- 6C Delivery Route
- 6D Efficacy in Challenge Model
- 7 Development of a vectored Brucella vaccine
- 74 Efficacy in Challenge Model
- 7A Safety
- 7B Delivery Route
- 7C Delivery Platform
Vaccine
Research Question
- The development of safe effective vaccines against B. abortus; B. melitensis; B. suis, allowing vaccinated to be differentiated from infected
B abortus and B. melitensis sometimes infect the same species so the development of a cross protective vaccine for cattle could be useful in some situations - The minimum requirement is that R0 to <1 in vaccinated herds/flocks but ideally resulting in sterile immunity.
Research Gaps and Challenges
- The development of a better vaccine based on the rational attenuation of the organism or on purified immunogens delivered by various mechanisms.
- Vaccines can sensitise animals to current diagnostic tests resulting in false positives.
Solution Routes
- Establish safety and protection levels with various candidate vaccine options, including priming with one vaccine and boosting with a different vaccine.
- Modelling level of vaccine coverage required to get R0 <1
- Establishing the impact of vaccination in carrier/persistently infected animals.
Dependencies
- Development of a novel attenuated vaccine that isn’t excreted
- Development of an inactivated vaccine
- Development of a subunit vaccine
- Development of a DNA vaccine
- Development of a vectored vaccine
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom