Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v18
Rationally attenuated genetically modified Brucella organisms
Next steps
- 3 Development of a novel Brucellosis attenuated vaccine allowing DIVA
- 3A Safety
- 3B Delivery Route
- 3C Delivery Platform
- 3D Efficacy in Challenge Model
- 9 Identifying suitable delivery systems for subunit vaccine candidates, killed bacteria and DNA vaccine candidates
Attenuated Organisms
Research Question
- Rational attenuation of Brucella by removing virulence genes so that it protects against infection but doesn’t cause disease
Research Gaps and Challenges
- That the GM bacterium is stable and can be grown in culture
Solution Routes
- Removal of one or more virulence genes and establishing viability and virulence/safety and immunogenicity of the resulting organism
Dependencies
- Identity of virulence factors
- Identity of immunomodulatory factors in the bacterium
Projects
What activities are planned or underway?
Estimates of disease burden caused by foodborne pathogens in contaminated dairy products in Rwanda.
Planned Completion date 06/04/2023
Source Countries:
Netherlands
An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania
Planned Completion date 14/07/2021
Source Countries:
Netherlands