Home ‹ Brucellosis ‹ [Identity of immunomodulators] To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections
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Roadmap for development of a candidate vaccine for Brucella

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To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections

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Dependencies

Next steps

Identity of immunomodulators

Research Question

  • Pathogens manipulate the immune responses of the host in an attempt to survive. Establishing how the various Brucella species manipulate the host’s immune response will allow these factors to be removed and thus allow the hosts immune system to react to the organism in a different way, possibly enhancing protection

Research Gaps and Challenges

  • Identifying deleterious immunomodulatory factors from ones that may be beneficial.

Solution Routes

  • Generation of a range of knock-out Brucella organisms where the genes for various immunomodulatory factors or other stealth mechanisms have been removed and their use in experimental infections.

Dependencies

  • Improved understanding of Brucella-macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)

Projects

What activities are planned or underway?

An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania

Planned Completion date 14/07/2021

Source Countries:

NetherlandsIconNetherlands

Would you bet on the vet? Influences on dairy farmers' vaccination choices, with a spotlight on the Veterinarian impact.

Planned Completion date 01/01/2024

Source Countries:

NetherlandsIconNetherlands