Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v116
To identify protective mechanisms in Brucella-infected animals
Dependencies
- 17 Host Pathogen interaction in Brucellosis infection
- 17A Entry
- 17B Replication
- 17C Persistence/Clearance
- 18 Pathogen Genome
Next steps
Identity of Mechanisms of Protection
Research Question
- Identify the mechanisms operating in immune animals, establishing the role of Abs and CMI in preventing and containing infection.
Solution Routes
- Characterising the innate immune responses of infected animals.
- To identify the role of CMI and Ab in providing protection against infection – passive transfer experiments; identity of cell types responding in recall responses.
- To establish the role of the various cell types and cytokine responses in preventing/clearing infection
- To characterise the cytokine and cellular responses in latency and carrier states.
- Identify biomarkers of immunity
Dependencies
- An improved understanding of host pathogen interaction at the level of the infected cells.
- The genome sequence of the various Brucella species, including s19, Rev 1 and RB51.
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom