Brucellosis roadmap:
Vaccines
Roadmap for development of a candidate vaccine for Brucella
Download Roadmap-for-a-brucella-vaccine-v112
Establishing the identity of protective antigens of the various Brucella species
Dependencies
- 13 Identification of the Brucella virulence factors that contribute to disease pathology
- 14 To establish the identity of the immunomodulatory factors and stealth mechanisms operating in Brucella infections
- 15 Host Responses to Natural Infection
- 16 To identify protective mechanisms in Brucella-infected animals
- 16A Antibody Response
- 16B Cell Mediated Immunity
Next steps
Identity of Protective Antigens
Research Question
- The identity the Brucella components that the host needs to respond to to prevent and contain infection
Research Gaps and Challenges
- Differentiating protective antigens from other antigens that the host is responding to which may be assisting the bacterium evade the hosts’ responses at a particular stage of infection.
- Identifying common antigens across the various Brucella species
- Immunogenicity vs virulence
Solution Routes
- To identify the antigens that are responsible for protective cellular responses.
- The identity of the antigens that the host is generating Abs to and their role in protection (preventing and clearing infection).
- Identifying possible protective antigens in the Brucella genome, their expression and trial in challenge experiments
Dependencies
- Identity of protective mechanisms operating in immune hosts – the role of cell-mediated immune responses and Abs.
- The genome sequence of various virus isolates
Projects
What activities are planned or underway?
EVOZOOM – Evolution and Zoonotic Epidemiology of Bovine Tuberculosis
Planned Completion date
Participating Country(s):
United Kingdom
Milk proteins in bovine mastitis: biomarkers of disease and biological function
Planned Completion date
Participating Country(s):
United Kingdom