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Identification of the Brucella virulence factors that contribute to disease pathology

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Dependencies

Next steps

Identity of Virulence Factor

Research Question

  • Identifying and removal of the factors contributing to pathological changes are essential for generating rationally attenuated vaccines

Research Gaps and Challenges

  • Immunogenicity may be linked to virulence

Solution Routes

  • Generation of a range of knock-out bacteria where putative virulence factors have been removed and their use in experimental infections

Dependencies

  • Improved understanding of Brucella – macrophage interaction – Brucella and macrophage gene expression in different in vivo environments (macrophages from naïve, immune and carrier hosts)

Projects

What activities are planned or underway?

Estimates of disease burden caused by foodborne pathogens in contaminated dairy products in Rwanda.

Planned Completion date 06/04/2023

Source Countries:

NetherlandsIconNetherlands

An overview of current approaches and challenges to the control of endemic infectious cattle diseases in Albania

Planned Completion date 14/07/2021

Source Countries:

NetherlandsIconNetherlands