Roadmap for the development of candidate vaccines for liver fluke
Download Liver-Fluke-Vaccine-Roadmap-118
Challenge model
Dependencies
- 17 Host pathogen interactions
- 17A Entry
- 17B Replication
- 17C Persistence clearance
Next steps
Research Question
What are we trying to achieve and why? What is the problem we are trying to solve?
- What are acceptable challenge models for screening of vaccine candidates
- Will we obtain different results with bolus as compared with trickle infections?
Research Gaps and Challenges
What are the scientific and technological challenges (knowledge gaps needing to be addressed)?
- Is there a difference in the vaccine response to trickle (field) and bolus challenges
- Can we predict differences in vaccine protection based on fluke strain
- Is there a non-challenge proxy for estimating protective capacity
Solution Routes
What approaches could/should be taken to address the research question?
Meta-analysis of previous trials used in an attempt to determine and standardise the optimum vaccine challenge model
Dependencies
What else needs to be done before we can solve this need?
- What would regulators accept in relation to minimal efficacy
- Understand the contribution of fluke genetic variability on protection following vaccination
State Of the Art
Existing knowledge including successes and failures
Protective effect has been observed using both trickle, and bolus, challenge models to date. The same is true for non-protective trials
Projects
What activities are planned or underway?
Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique
Planned Completion date 14/09/2022
Netherlands
BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)
Planned Completion date 31/01/2028
Denmark