Roadmap for the development of candidate vaccines for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

To refine and better standardise reproducible FMD challenge model in the different species (especially in pigs).

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Define in vitro homologous and heterologous correlates of protection
• In vitro quality control methods (reduce animal use, at least to reduce number of batches tested, also including ruminants)
• Improve reproducibility in pigs’ study (e.g. point of inoculation, need of trained personnel)
• Define dose
• Determine a unique point of inoculation for challenge
• Develop methods for measure the viral clearance during challenge.

What approaches could/should be taken to address the research question?

• Shall not look at individual responses while using grouped animals
• Use of big data, using already available data

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures