Coronaviruses roadmap:
Diagnostic Tests
Roadmap for the development of diagnostic tests for coronaviruses
Download 202410 Draft Coronavirus Diagnostic Development_Final8
Characterisation
Characterisation
Research Question
- Genetic/biological characterisation of major coronaviruses impacting animal health and/or having zoonotic concerns
Research Gaps and Challenges
- Characterise determinants of high vs low virulence
- Characterisation of and host range host/issue tropism
- Characterisation of the antigenic properties
- General genetic similarity between many coronavirus lineages, therefore sequencing is needed for species identification
- What features characterise new variants of concern?
- Lack of standardised tools for basic biological characterisation
- Lack of adequate cell lines for isolation and characterisation
- Characterisation of major drivers for virus jumping into new species of hosts
- Understanding the effect (if any) of propagating viruses in cell lines / organoids on the phenotype of the virus
Solution Routes
- Somatic Mutagenesis (ISA)- to rescue synthetic viruses
- Loss of function experiments by reverse genetics strategies
- Study virus transmission across human/animal interface and animal/animal interface
- Development of models to predict epitopes based on S sequence evolution
- Improve ex vivo, in vitro and organoids characterization of new viral isolates
Dependencies
- Virus isolates
- Standardised animal models to characterise virus
- Interface transmission models
- Genomic surveillance in multiple hosts and even different sites within the same host
Projects
What activities are planned or underway?
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Source Countries:
Europe
PARTNERSHIP: RAPID DETECTION OF INCURSIONS OF SARS-COV-2 AND NOVEL CORONAVIRUSES ON TEXAS MEAT AND DAIRY FARMS
Planned Completion date 31/08/2028
Source Countries:
United Kingdom