Home ‹ Helminths (including anthelmintic resistance) ‹ [DNA/RNA vaccines] – Development of nucleic acid-based vaccines – Liver Fluke
Helminths (including anthelmintic resistance) roadmap:
Vaccines

Roadmap for the development of candidate vaccines for liver fluke

Download Liver-Fluke-Vaccine-Roadmap-1

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DNA/RNA vaccines

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Dependencies

Next steps

Development of nucleic acid-based vaccines

Research Question

What are we trying to achieve and why? What is the problem we are trying to solve?

Generation of a protective immune response against F.hepatica

Research Gaps and Challenges

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

DNA vaccine approach hasn’t worked as well in ruminants as in rodent models.
Anticipated regulatory challenges for this approach

Solution Routes

What approaches could/should be taken to address the research question?

  • DNA vaccine
  • Self-amplifying RNA technology
  • Efficacy trials of existing candidates in experimental and field challenge studies

Dependencies

What else needs to be done before we can solve this need?

  • A challenge model
  • Definition of minimal acceptable efficacy
  • Identity of protective antigens
  • Identity of suitable molecular adjuvants

State Of the Art

Existing knowledge including successes and failures

Very limited evidence in the target species

Projects

What activities are planned or underway?

Single-nucleotide polymorphisms in the beta-tubulin gene and its relationship with treatment response to albendazole in human soil-transmitted helminths in Southern Mozambique

Planned Completion date 14/09/2022

Source Countries:

NetherlandsIconNetherlands

BruchidRESIST: The Pannonian vetch (Vicia pannonica) as a model plant for the development of resistant field bean and vetch varieties against field bean weevil (Bruchus rufimanus) infestation (BruchidRESIST)

Planned Completion date 31/01/2028

Source Countries:

DenmarkIconDenmark