Coronaviruses roadmap:
Control Strategies
Roadmap for the development of disease control strategies for coronaviruses
Download 202410 Draft Coronavirus Disease control research roadmap Final13
Host genetics
Host genetics
Research Question
- Understand how host genetics influence susceptibility to coronavirus infections
Research Gaps and Challenges
- Identifying specific genetic variants linked to immune response and understanding their mechanisms
- Interdisciplinary collaboration to bridge existing knowledge gaps
- Lack of SNP CHiP data reporting guidelines and online repository so sharing and using this data is very challenging
Solution Routes
- Large scale Genome Wide Association Studies (GWAS)
- CRISPR-Cas9, and other gene-editing technologies, for functional genomics to study genetic variants and their role in immune response
- Population genetic studies focusing in identifying protective alleles
- Multi-omics approaches
- Models to integrate genetic, transcriptomic, and clinical data, to understand interactions between genetic variants and immune responses
Dependencies
- Advanced genomic techniques
- Bioinformatics systems
- Establishment of infrastructure for data management and interpretation
- Farms cannot manage the recording necessary for phenotypes and genotypes
- Public acceptance
Projects
What activities are planned or underway?
Differential susceptibility of SARS-CoV-2 in animals : Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation
Planned Completion date 26/07/2021
Participating Country(s):
Netherlands
Veterinary Biocontained facility Network for excellence in animal infectiology research and experimentation
Planned Completion date 28/02/2023
Participating Country(s):
Europe