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Roadmap for the development of disease control strategies for influenza

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Host genetics

Host genetics

Research Question

  • Improve knowledge of host genetics in relation to susceptibility

Research Gaps and Challenges

  • How to manipulate bird genetics and / or anti – viral state responses without vaccine use?
  • Any new genetic improvement has a cost on the physiology (e.g. birds will grow more slowly)
  • Understanding the genetic behind the host immune systems of resistant animals (e.g. ducks/ostriches)

Solution Routes

  • Identify molecular markers of host range in different birds (we know a lot more about what it takes for a virus to transmit from birds to
    humans than the same about different bird species)
  • NGS , variant analysis bioinformatics tools , combined with experimental in vivo studies in different bird species – Host / virus risk
    assessment matrix
  • Study of host genomes for identifying factors contributing to resistance
  • Improve the immune responses of hosts to vaccination (turkeys especially)
  • Transgenomic studies of infected ostriches/ducks to determine the resistant genes and how they can be bred into poultry
  • Evaluate the impact of developing more resistant hosts that will live among humans and wildlife that are still susceptible
  • Study immunization capacities of vaccination and genetics modification combined

Dependencies

  • Better understanding of avian immunology
  • Acceptance of consumers in case of GM

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands