African Swine Fever roadmap:
Control Strategies
Roadmap for the development of control strategies for ASF
Download ASF Control Strategy Roadmap18
Host genetics
Next steps
Host genetics
Research Question
- There is a lack of available sequences for host genomes of ASFV susceptible species, including the species and subspecies of both domestic and wild pigs in endemic or outbreak areas, and the genomic sequences of animals that are able to survive an outbreak
- In order to conduct genomic studies as to what factors contribute to resistance of some of these breeds, a large-scale sequencing effort should be conducted
Research Gaps and Challenges
- Obtaining genomic sequences of the wild and domestic pigs, boar and warthogs in outbreak areas
- Development of CRISPR/Cas9 or siRNA libraries targeting swine genomes
Solution Routes
- Development of a swine specific knockout libraries are critical for in vitro genomic screens for ASFV. Libraries targeting the swine genome would be highly valuable to perform host genomic screens for ASFV for a wide range of experimental avenues that could lead to the discovery of potential receptors, pathways modulated to avoid immune detection or for increased virus virulence
State Of the Art
- The course of ASF infection varies depending not only on the particular virus strain but also on host characteristics. Fourteen individual genomes are available from breeds of Sus scrofa on NCBI, but the genome sequences of the wild and domestic pigs, boar and warthogs in outbreak areas of Africa and Europe remains largely unknown
Projects
What activities are planned or underway?
The impact of temperature on transmission of African swine fever in contaminated livestock vehicles
Planned Completion date 01/01/2023
Source Countries:
Netherlands
A Multi-Laboratory Comparison of Methods for Detection and Quantification of African Swine Fever Virus.
Planned Completion date 07/03/2022
Source Countries:
Netherlands