Influenza roadmap:
Control Strategies
Roadmap for the development of disease control strategies for influenza
Download Influenza-control-development-roadmap9
Host-pathogen-environment interactions
Dependencies
Next steps
Host-pathogen-environment interactions
Research Question
- Improved understanding of the host-pathogen-environmental interactions
Research Gaps and Challenges
- Understanding the mechanisms behind increased pathogenicity observed with some H9N2 and H5N2 LPAI strains
- Clades and strain and subtype differences complicated a single way to address the issues
- Potential role of the vasculature in HPAI pathogenesis
- Consequences for disease ecology in wild bird species of the wide range of avian species susceptibility of H5N1
- Understanding why some duck species are resistant to infection and disease compared to terrestrial poultry
- Are there better ways to cluster groups of viruses that behave similarly to have groups of solution?
- Role of maternal immunity and vaccination in disease transmission
- Role of scavengers (dogs, cats, birds) and carriers like rats in infected
premises
Solution Routes
- Increasing understanding of potential reservoir species at the human/animal interface
- Monitoring of point-of-entry into high-risk areas (introduction of HPAI from Asia/Europe to Nigeria) via migratory waterfowl
- Viral, host, and environmental factors that influence the risk of acquiring an HA multibasic cleavage site
- Transmission experimental models for complex biological systems e.g., live bird markets, ponds where wild birds gather, bird feeders, sow
barns - Quantify the transmission role of scavengers (dogs, cats, birds) and carriers like rats in infected premises
Dependencies
- Standardization of pathogenesis/transmission models and experimental influenza delivery routes
Projects
What activities are planned or underway?
Development of Vaccines for HPAI in Cattle, Turkey, Pigs, and Small Ruminants and Food Safety Studies Related to HPAI Virus in Food Products
Planned Completion date 25/08/2029
Source Countries:
United States
Automated non-invasive Detection of Surface Contamination and Optimizing Surface Biofilm Removal Conditions in Large-Scale Food Processing Equipment
Planned Completion date 31/08/2028
Source Countries:
United States