Porcine Reproductive & Respiratory Syndrome roadmap:
Vaccines
Roadmap for development of a candidate vaccine for PRRSV
Download PRRSV Vaccine Roadmap17
Host-pathogen interactions
Dependencies
- 18 Pathogen genome
Next steps
- 15 Host responses to natural infection
- 14 Identity of immunomodulators
- 13 Identity of virulence factors
- 16 Identity of mechanisms of protection
- 16A Antibody response
- 16B Cell-mediated immunity
Host-pathogen interaction in PRRSV infection
Research Question
- To gain an improved understanding of how PRRSV enters, replicates and survives in and is released from infected cells
Research Gaps and Challenges
- PRRSV infects macrophages which are an important contributor to the immune response so establishing how the virus interacts with macrophages is central to identifying the protective mechanisms and how the virus evades them.
Solution Routes
- Establish the basis of virulence/pathogenicity – including in high virulence strains – is it related to related to inflammatory response or viral replication
- Viral and macrophage gene expression in different in vivo environments (macrophages from naïve and immune hosts)
- Comparative response to highly pathogenic/virulent and mild/attenuated strains of the virus
- Role of GP5 and Protein M peptides and binding
Dependencies
- The genome sequence of various PRRSV isolates
Projects
What activities are planned or underway?
Immune responses induced by inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine in neonate pigs using different adjuvants
Planned Completion date 01/02/2021
Source Countries:
Netherlands
Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.
Planned Completion date 12/01/2024
Source Countries:
Netherlands