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Persistence/clearance

Persistence/clearance

Research Question

  • Identify the factors that influences susceptibility/resistance to infection

Research Gaps and Challenges

  • Understand how stress influences virus susceptibility
  • Improved understanding of the mechanisms of resistance of some species of fowl and endemic situation in swine
  • Levels of immune expression in different species due to virus infection

Solution Routes

  • Study the mechanisms of resistance of ducks to HPAIV infection compared to other birds
  • Identify the host factors that influences high susceptibility of turkeys to HPAIV
  • Genetic determinants of resistance to HPAI strains in known reservoir species (e.g. ducks)
  • Mechanism of action of duck RIG-I in conferring AI resistance, and whether there are homologues in other avian species
  • Information on a possible carrier state in some species or immune-suppressed individuals
  • Understand how some LPAIV subtypes can affect the immune response and subsequent susceptibility/restriction to further infection
  • Identification of carrier bird species
  • Research on memory T cell immunity against AI, because is present for short period of time (months)

Dependencies

  • Existence of carrier state in some species (pheasants) or immunocompromised animals
  • Understanding the routes of transmission in different species
  • Breeding conditions are extremely important for successful vaccination

Projects

What activities are planned or underway?

Protect wildlife from livestock diseases.

Planned Completion date 07/10/2022

Participating Country(s):

NetherlandsIconNetherlands

Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta

Planned Completion date 21/10/2024

Participating Country(s):

NetherlandsIconNetherlands