Influenza roadmap:
Vaccines
Roadmap for the development of candidate vaccines for influenza
Download Influenza-vaccine-development-roadmapC
Persistence/clearance
Persistence/clearance
Research Question
- Identify the factors that influences susceptibility/resistance to infection
Research Gaps and Challenges
- Understand how stress influences virus susceptibility
- Improved understanding of the mechanisms of resistance of some species of fowl and endemic situation in swine
- Levels of immune expression in different species due to virus infection
Solution Routes
- Study the mechanisms of resistance of ducks to HPAIV infection compared to other birds
- Identify the host factors that influences high susceptibility of turkeys to HPAIV
- Genetic determinants of resistance to HPAI strains in known reservoir species (e.g. ducks)
- Mechanism of action of duck RIG-I in conferring AI resistance, and whether there are homologues in other avian species
- Information on a possible carrier state in some species or immune-suppressed individuals
- Understand how some LPAIV subtypes can affect the immune response and subsequent susceptibility/restriction to further infection
- Identification of carrier bird species
- Research on memory T cell immunity against AI, because is present for short period of time (months)
Dependencies
- Existence of carrier state in some species (pheasants) or immunocompromised animals
- Understanding the routes of transmission in different species
- Breeding conditions are extremely important for successful vaccination
Projects
What activities are planned or underway?
Protect wildlife from livestock diseases.
Planned Completion date 07/10/2022
Participating Country(s):
Netherlands
Dynamics of sustainability in integrated agriculture : aquaculture systems in the Mekong Delta
Planned Completion date 21/10/2024
Participating Country(s):
Netherlands