Roadmap for the research to underpin the development of control strategies for FMD

What are we trying to achieve and why? What is the problem we are trying to solve?

To identify determinants of viral virulence for different serotypes of FMDV in cattle, sheep, and swine.

What are the scientific and technological challenges (knowledge gaps needing to be addressed)?

• Investigate variability of virulence across cattle breeds.
• Identify determinants of viral virulence for different serotypes of FMDV in cattle, sheep, and swine.

What approaches could/should be taken to address the research question?

What else needs to be done before we can solve this need?

Existing knowledge including successes and failures

There are differences in FMDV pathogenesis among animal species: ruminants, in contrast to pigs, are highly susceptible to infection by the respiratory route. They may be infected experimentally by airborne exposure with doses over 103 times lower than pigs. This coincides with differences in the primary sites of viral replication and primary responses to infection between these two animal species.